Our Mission

Autoimmune diseases as a group pose an increasing threat to our health system. However, our understanding about the emergence of autoimmune diseases is relatively scarce and current treatment options are limited to unspecific systemic immune suppression, which results in severe side effects including an increased vulnerability to infections.
The CRC 1526  aims to elucidate the initial events leading to the emergence of autoimmune diseases and develop novel therapeutic and diagnostic strategies, that allow the early detection and site-specific treatment of autoimmune diseases. We will exploit the properties of pemphigoid diseases as a group of prototypical tissue-specific autoimmune disease and subsequently assess, if gained insights are  transferable to other (tissue-specific) autoimmune diseases.

Development of the CRC 1526

Establishment of the CRC 1526 at the University of Lübeck is the result of almost two decades of successful research on pemphigoid diseases. The research at the University of Lübeck  not only established novel preclinical mouse models, but also characterized the mechanisms during the active phase of the disease and was a major contributor to identify the targeted autoantigens resulting to the formation of the disease; therefore, established pemphigoid diseases as prototypical tissue-specific autoimmune diseases.

This work is now continued and extended by the establishment of the CRC 1526.

Click here for a more detailed description of the steps leading to the establishment of the CRC 1526.

Early career support

Promotion of young scientist is the cornerstone of every successful research project and one of the central key objectives of the CRC 1526. Therefore, the development of all PhD and MD candidates will be supported by programs of one of the following research training groups (RTG):

By this means we  ensure an exellent scientific training of our PhD candidates and also allow the formation of a research networt at the beginning of their career.

Involved Departments