2025
N.
Gross,
A.
Jochimsen,
S.
Dräger,
T.
Theocharis,
A.
Recke,
N.
Beek,
L.
Schmidt-Jiménez,
S.
Krohn,
K.
Klausz,
K.
Bieber,
R.
Ludwig, and
M.
Peipp,
CD19xCD3 bispecific T cell engager treatment induces remission in experimental pemphigoid disease, bioRxiv , Sep. 2025.
CD19xCD3 bispecific T cell engager treatment induces remission in experimental pemphigoid disease, bioRxiv , Sep. 2025.
| DOI: | 10.1101/2025.09.09.675030 |
M.
Buenning,
S.
Purusothaman,
S.
Symannek,
P.
Curman,
K.
Kridin,
E.
Schmidt,
K.
Bieber, and
R.
Ludwig,
Differential risks of venous thromboembolic events in pemphigus and pemphigoid diseases, Journal of the European Academy id Dermatology & Venereology , Aug. 2025.
Differential risks of venous thromboembolic events in pemphigus and pemphigoid diseases, Journal of the European Academy id Dermatology & Venereology , Aug. 2025.
| DOI: | 10.1111/jdv.70017 |
A.
Mahdy,
J.
Fuß,
S.
Franzenburg,
M.
Vollstedt,
Y.
Dolshanskaya,
Kokubun,
V.
Kriukova,
F.
Tran,
C.
Bang,
M.
Hoivik,
J.
Skieceviciene,
J.
Kupcinskas,
M.
Poyet,
A.
Franke, and
H.
ElAbd,
Quantifying The Impact of Bulk TCR-Seq Methodological Choices on The Profiled T Cell Repertoire, bioRxiv , Aug. 2025.
Quantifying The Impact of Bulk TCR-Seq Methodological Choices on The Profiled T Cell Repertoire, bioRxiv , Aug. 2025.
| DOI: | 10.1101/2025.08.05.668736 |
H.
Olbrich,
S.
Preuß,
K.
Kridin,
G.
Hernandez,
D.
Thaci,
R.
Ludwig, and
P.
Curman,
COVID-19 infection raises respiratory type-2 inflammation disease risk, whereas vaccination is protective, The Journal of Allergy and Clinical Immunology , Jul. 2025.
COVID-19 infection raises respiratory type-2 inflammation disease risk, whereas vaccination is protective, The Journal of Allergy and Clinical Immunology , Jul. 2025.
| DOI: | 10.1016/j.jaci.2025.07.030 |
L.
Bao,
C.
Guerrero-Juarez,
J.
Li,
M.
Pigors,
S.
Emtenani,
Y.
Liu,
A.
Mansini,
Y.
Wang,
A.
Ahmed,
N.
Ishii,
T.
Hashimoto,
B.
White,
S.
Green,
K.
Kunstman,
N.
Nowak,
C.
Cole,
M.
Sarkar,
J.
Gudjonsson,
M.
Virgilia,
M.
Sverdlov,
M.
McAlexander,
C.
McCrae,
C.
Nazaroff,
E.
Schmidt, and
K.
Amber,
IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent proinflammatory response in keratinocytes, nature communications , Jul. 2025.
IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent proinflammatory response in keratinocytes, nature communications , Jul. 2025.
| DOI: | 10.1038/s41467-025-62495-2 |
S.
Dräger,
C.
Kauderer,
S.
Meyhöfer,
L.
Dräger,
J.
Marquardt,
R.
Ludwig,
S.
Arndt,
K.
Boch, and
K.
Bieber,
Sita- and saxagliptin use and autoantibodies to autoimmune bullous diseases: A cross-sectional study, Journal of the European Academy of Dermatology & Venereology , Jun. 2025.
Sita- and saxagliptin use and autoantibodies to autoimmune bullous diseases: A cross-sectional study, Journal of the European Academy of Dermatology & Venereology , Jun. 2025.
| DOI: | 10.1111/jdv.20885 |
P.
Curman,
S.
Dräger,
H.
Olbrich,
G.
Hernandez,
K.
Bieber,
E.
Gaffal,
K.
Kridin,
S.
Szymczak, and
R.
Ludwig,
Identifying common risk factors for primary cellulitis in a large-scale retrospective cohort study, Preprints with THE LANCET , May 2025.
Identifying common risk factors for primary cellulitis in a large-scale retrospective cohort study, Preprints with THE LANCET , May 2025.
| DOI: | 10.2139/ssrn.5246532 |
K.
Yilmaz,
S.
Goletz,
C.
Hammers,
K.
Boch,
C.
Zeidler,
H.
Wiegmann,
E.
Bergmann,
T.
Lari,
O.
Dikmen,
N.
Härding,
R.
Strohal,
A.
Kleinheinz,
E.
Hadaschik,
N.
Beek,
S.
Ständer, and
E.
Schmidt,
Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series, Journal der Deutshen Dermatologischen Gesellschaft , May 2025.
Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series, Journal der Deutshen Dermatologischen Gesellschaft , May 2025.
| DOI: | 10.1111/ddg.15838 |
B.
Laffer,
M.
Ohms,
S.
Kenno,
P.
Tsui,
E.
Ehlers-Jeske,
W.
Song,
W.
Song, and
J.
Köhl,
Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoiummune blistering dermatosis, Frontiers in Immunology , Apr. 2025.
Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoiummune blistering dermatosis, Frontiers in Immunology , Apr. 2025.
| DOI: | DOI: 10.3389/fimmu.2025.1560468 |
S.
Schacht,
J.
Graffunder,
P.
Durek,
J.
Wehrenberg,
A.
Siracusa,
C.
Biese,
M.
Mashreghi,
K.
Thurley,
L.
Bauer, and
A.
Hutloff,
Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node, Cellular & Molecular Immunology , Apr. 2025.
Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node, Cellular & Molecular Immunology , Apr. 2025.
| DOI: | 10.1038/s41423-025-01285-8 |
S.
Stenger,
A.
Vorobjev,
K.
Bieber,
T.
Lange,
R.
Ludwig, and
J.
Hundt,
Insomnia increases the risk for specific autoimmune diseases: a large-scale retroperspective cohort study, Frontiers in Network Physiology , Apr. 2025.
Insomnia increases the risk for specific autoimmune diseases: a large-scale retroperspective cohort study, Frontiers in Network Physiology , Apr. 2025.
| DOI: | 10.3389/fnetp.2025.1499297 |
M.
Hibino,
T.
Filosi,
L.
Carrion,
E.
Porcu,
A.
Malhotra,
K.
Lüdtke-Buzug,
S.
Ibrahim,
Y.
Yamada, and
M.
Hirose,
An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter, Biomedicine & Pharmacotherapy , Apr. 2025.
An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter, Biomedicine & Pharmacotherapy , Apr. 2025.
| DOI: | 10.1016/j.biopha.2025.118019 |
H.
Wu,
M.
Prados, and
M.
Vaeth,
Metabolic Regulation of T Cell Exhaustion, Immune Discovery , Mar. 2025.
Metabolic Regulation of T Cell Exhaustion, Immune Discovery , Mar. 2025.
| DOI: | 10.70322/immune.2025.10005 |
M.
Tigges,
S.
Dräger,
I.
Piccini,
K.
Bieber,
A.
Vorobjev,
J.
Edelkamp,
M.
Bertolini, and
R.
Ludwig,
Pemphigoid disease model systems for clinical translation, Frontiers in Immunology , Mar. 2025.
Pemphigoid disease model systems for clinical translation, Frontiers in Immunology , Mar. 2025.
| DOI: | 10.3389/fimmu.2025.1537428 |
S.
Preuß,
K.
Bieber,
A.
Vorobyev,
A.
Recke,
E.
Moderegger,
H.
Zirpel,
E.
Gaffal,
D.
Thaci,
K.
Kridin, and
R.
Ludwig,
Dupilumab shows no elevated risk for maternal adverse pregnancy outcomes: A propensity-matched cohort study, Journal of the European Academy of Dermatology & Venereology , Mar. 2025.
Dupilumab shows no elevated risk for maternal adverse pregnancy outcomes: A propensity-matched cohort study, Journal of the European Academy of Dermatology & Venereology , Mar. 2025.
| DOI: | 10.1111/jdv.20670 |
R.
Ludwig,
M.
Anson,
H.
Zirpel,
D.
Thaci,
H.
Olbrich,
K.
Bieber,
K.
Kridin,
A.
Dempfle,
P.
Curman,
S.
Zhao, and
U.
Alam,
A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX, Frontiers in Pharmacology , Mar. 2025.
A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX, Frontiers in Pharmacology , Mar. 2025.
| DOI: | 10.3389/fphar.2025.1516126 |
V.
Hartmann,
S.
Guo,
S.
Rahimi,
U.
Radine,
D.
Malheiros,
A.
Salviano-Silva,
V.
Hoch,
G.
Cipolla,
V.
Calonga-Solis,
A.
Künstner,
I.
Burmester,
R.
Ludwig,
W.
Hariton,
C.
Hammers,
E.
Müller,
H.
Busch, and
J.
Hundt,
In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long lasting transcriptomic and proteomic changes, bioRxiv , Feb. 2025.
In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long lasting transcriptomic and proteomic changes, bioRxiv , Feb. 2025.
| DOI: | 10.1101/2025.02.10.637416 |
K.
Kridin,
C.
Papara,
K.
Bieber,
D.
Luca,
J.
Klein,
M.
Ludwig,
P.
Curman,
A.
Vorobyev,
A.
Dempfle, and
R.
Ludwig,
Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retroperspective cohort study, Frontoers in Psychiatry , Feb. 2025.
Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retroperspective cohort study, Frontoers in Psychiatry , Feb. 2025.
| DOI: | 10.3389/fpsyt.2025.1429297 |
J.
Kwon,
H.
Kawase,
K.
Mattonet,
S.
Guenther,
L.
Hahnefeld,
J.
Shamasara,
J.
Heering,
M.
Kurz,
S.
Kirchhofer,
C.
Krasel,
M.
Ulrich,
M.
Presechino,
S.
Murthy,
C.
ORlandi,
C.
Saidk,
G.
Geisslinger,
M.
Bünemann,
P.
Kolb,
S.
Offermanns, and
N.
Wettschureck,
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling, nature communications , Feb. 2025.
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling, nature communications , Feb. 2025.
| DOI: | 10.1038/s41467-025-56713-0 |
S.
Mousavi,
K.
Bieber,
H.
Zirpel,
A.
Vorobyev,
H.
Olbrich,
C.
Papara,
D.
Luca,
D.
Thaci,
E.
Schmidt,
G.
Riemekasten,
P.
Lamprecht,
M.
Laudes,
K.
Kridin, and
R.
Ludwig,
Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatroy diseases, Frontiers in Endocrinology , Feb. 2025.
Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatroy diseases, Frontiers in Endocrinology , Feb. 2025.
| DOI: | 10.3389/fendo.2025.1516433 |
T.
Lari,
L.
Macias,
L.
Robrahn,
H.
Dikmen,
J.
Prüßmann,
C.
Kiehne,
S.
Engster,
I.
Weyers,
S.
Szymczak,
N.
Beek,
M.
Hoffmann,
E.
Schmidt, and
S.
Emtenani,
Localization of Lesions in Autoimmune Blistering Diseases Is Independent of Site-Speicific Target Antigen Expression, Life , Jan. 2025.
Localization of Lesions in Autoimmune Blistering Diseases Is Independent of Site-Speicific Target Antigen Expression, Life , Jan. 2025.
| DOI: | 10.3390/life15020218 |
2024
C.
Saggau,
P.
Bacher,
D.
Esser,
M.
Rasa,
S.
Meise,
N.
Mohr,
N.
Kohlstedt,
A.
Hutloff,
S.
Schacht,
J.
Dargvainiene,
G.
Martini,
K.
Stürner,
I.
Schröder,
R.
Markewitz,
J.
Hartl,
M.
Hastermann,
A.
Duchow,
P.
Schindler,
M.
Becker,
C.
Bautista,
J.
Gottfreund,
J.
Walter,
J.
Polansky,
M.
Yang,
R.
Naghavian,
M.
Wendorff,
E.
Schuster,
A.
Dahl,
A.
Petzold,
S.
Reinhardt,
A.
Franke,
M.
Wieczorek,
L.
Henschel,
D.
Berger,
G.
Heine,
M.
Holtsche,
V.
Häußler,
C.
Peters,
E.
Schmidt,
S.
Fillatreau,
D.
Busch,
K.
Wandinger,
K.
Schober,
R.
Martin,
F.
Paul,
F.
Leypoldt, and
A.
Scheffold,
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases, Immunity , Oct. 2024.
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases, Immunity , Oct. 2024.
| DOI: | DOI: 10.1016/j.immuni.2024.08.005 |
K.
Stark,
B.
Kilani,
S.
Stockhausen,
J.
Busse,
I.
Schubert,
T.
Tran,
F.
Gaertner,
A.
Leuning,
K.
Pekayvaz,
L.
Nicolai,
V.
Fumagalli,
J.
Stermann,
F.
Stephan,
C.
David,
M.
M??ller,
B.
Heyman,
A.
Lux,
A.
Guerreiro,
L.
Frenzel,
C.
Schmidt,
A.
Dopler,
M.
Moser,
S.
Chandrarantne,
M.
Brühl,
M.
Lorenz,
T.
Korff,
M.
Rudelius,
O.
Popp,
M.
Kirchner,
P.
Mertins,
F.
Nimmerjahn,
M.
Iannacone,
M.
Sperandio,
B.
Engelmann,
A.
Verschoor, and
S.
Massberg,
Antibodies and complement are key drivers of thrombosis, Immunity , Sep. 2024.
Antibodies and complement are key drivers of thrombosis, Immunity , Sep. 2024.
| DOI: | 10.1016/j.immuni.2024.08.007 |
M.
Olbrich,
S.
Patzelt,
C.
Sadik,
E.
Schmidt, and
R.
Ludwig,
Risk of blindness in a global cohort of patients with mucous membrane pemphigoid, Pharmacological Research , Sep. 2024.
Risk of blindness in a global cohort of patients with mucous membrane pemphigoid, Pharmacological Research , Sep. 2024.
| DOI: | 10.1111/jdv.20499 |
J.
Tegtmeyer,
M.
Romagnuolo,
C.
Hammers,
B.
Opelka,
C.
Probst,
L.
Komorowski,
A.
Marzano,
E.
Schmidt, and
S.
Goletz,
Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease, Experimental Dermatology , Jun. 2024.
Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease, Experimental Dermatology , Jun. 2024.
| DOI: | DOI: 10.1111/exd.15125 |
