2025
P.
Curman,
S.
Dräger,
H.
Olbrich,
G.
Hernandez,
K.
Bieber,
E.
Gaffal,
K.
Kridin,
S.
Szymczak, and
R.
Ludwig,
Identifying common risk factors for primary cellulitis in a large-scale retrospective cohort study, Preprints with THE LANCET , May 2025.
Identifying common risk factors for primary cellulitis in a large-scale retrospective cohort study, Preprints with THE LANCET , May 2025.
| DOI: | 10.2139/ssrn.5246532 |
B.
Laffer,
M.
Ohms,
S.
Kenno,
P.
Tsui,
E.
Ehlers-Jeske,
W.
Song,
W.
Song, and
J.
Köhl,
Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoiummune blistering dermatosis, Frontiers in Immunology , Apr. 2025.
Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoiummune blistering dermatosis, Frontiers in Immunology , Apr. 2025.
| DOI: | DOI: 10.3389/fimmu.2025.1560468 |
S.
Schacht,
J.
Graffunder,
P.
Durek,
J.
Wehrenberg,
A.
Siracusa,
C.
Biese,
M.
Mashreghi,
K.
Thurley,
L.
Bauer, and
A.
Hutloff,
Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node, Cellular & Molecular Immunology , Apr. 2025.
Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node, Cellular & Molecular Immunology , Apr. 2025.
| DOI: | 10.1038/s41423-025-01285-8 |
S.
Stenger,
A.
Vorobjev,
K.
Bieber,
T.
Lange,
R.
Ludwig, and
J.
Hundt,
Insomnia increases the risk for specific autoimmune diseases: a large-scale retroperspective cohort study, Frontiers in Network Physiology , Apr. 2025.
Insomnia increases the risk for specific autoimmune diseases: a large-scale retroperspective cohort study, Frontiers in Network Physiology , Apr. 2025.
| DOI: | 10.3389/fnetp.2025.1499297 |
M.
Hibino,
T.
Filosi,
L.
Carrion,
E.
Porcu,
A.
Malhotra,
K.
Lüdtke-Buzug,
S.
Ibrahim,
Y.
Yamada, and
M.
Hirose,
An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter, Biomedicine & Pharmacotherapy , Apr. 2025.
An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter, Biomedicine & Pharmacotherapy , Apr. 2025.
| DOI: | 10.1016/j.biopha.2025.118019 |
H.
Wu,
M.
Prados, and
M.
Vaeth,
Metabolic Regulation of T Cell Exhaustion, Immune Discovery , Mar. 2025.
Metabolic Regulation of T Cell Exhaustion, Immune Discovery , Mar. 2025.
| DOI: | 10.70322/immune.2025.10005 |
M.
Tigges,
S.
Dräger,
I.
Piccini,
K.
Bieber,
A.
Vorobjev,
J.
Edelkamp,
M.
Bertolini, and
R.
Ludwig,
Pemphigoid disease model systems for clinical translation, Frontiers in Immunology , Mar. 2025.
Pemphigoid disease model systems for clinical translation, Frontiers in Immunology , Mar. 2025.
| DOI: | 10.3389/fimmu.2025.1537428 |
S.
Preuß,
K.
Bieber,
A.
Vorobyev,
A.
Recke,
E.
Moderegger,
H.
Zirpel,
E.
Gaffal,
D.
Thaci,
K.
Kridin, and
R.
Ludwig,
Dupilumab shows no elevated risk for maternal adverse pregnancy outcomes: A propensity-matched cohort study, Journal of the European Academy of Dermatology & Venereology , Mar. 2025.
Dupilumab shows no elevated risk for maternal adverse pregnancy outcomes: A propensity-matched cohort study, Journal of the European Academy of Dermatology & Venereology , Mar. 2025.
| DOI: | 10.1111/jdv.20670 |
R.
Ludwig,
M.
Anson,
H.
Zirpel,
D.
Thaci,
H.
Olbrich,
K.
Bieber,
K.
Kridin,
A.
Dempfle,
P.
Curman,
S.
Zhao, and
U.
Alam,
A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX, Frontiers in Pharmacology , Mar. 2025.
A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX, Frontiers in Pharmacology , Mar. 2025.
| DOI: | 10.3389/fphar.2025.1516126 |
V.
Hartmann,
S.
Guo,
S.
Rahimi,
U.
Radine,
D.
Malheiros,
A.
Salviano-Silva,
V.
Hoch,
G.
Cipolla,
V.
Calonga-Solis,
A.
Künstner,
I.
Burmester,
R.
Ludwig,
W.
Hariton,
C.
Hammers,
E.
Müller,
H.
Busch, and
J.
Hundt,
In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long lasting transcriptomic and proteomic changes, bioRxiv , Feb. 2025.
In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long lasting transcriptomic and proteomic changes, bioRxiv , Feb. 2025.
| DOI: | 10.1101/2025.02.10.637416 |
K.
Kridin,
C.
Papara,
K.
Bieber,
D.
Luca,
J.
Klein,
M.
Ludwig,
P.
Curman,
A.
Vorobyev,
A.
Dempfle, and
R.
Ludwig,
Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retroperspective cohort study, Frontoers in Psychiatry , Feb. 2025.
Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retroperspective cohort study, Frontoers in Psychiatry , Feb. 2025.
| DOI: | 10.3389/fpsyt.2025.1429297 |
J.
Kwon,
H.
Kawase,
K.
Mattonet,
S.
Guenther,
L.
Hahnefeld,
J.
Shamasara,
J.
Heering,
M.
Kurz,
S.
Kirchhofer,
C.
Krasel,
M.
Ulrich,
M.
Presechino,
S.
Murthy,
C.
ORlandi,
C.
Saidk,
G.
Geisslinger,
M.
Bünemann,
P.
Kolb,
S.
Offermanns, and
N.
Wettschureck,
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling, nature communications , Feb. 2025.
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling, nature communications , Feb. 2025.
| DOI: | 10.1038/s41467-025-56713-0 |
S.
Mousavi,
K.
Bieber,
H.
Zirpel,
A.
Vorobyev,
H.
Olbrich,
C.
Papara,
D.
Luca,
D.
Thaci,
E.
Schmidt,
G.
Riemekasten,
P.
Lamprecht,
M.
Laudes,
K.
Kridin, and
R.
Ludwig,
Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatroy diseases, Frontiers in Endocrinology , Feb. 2025.
Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatroy diseases, Frontiers in Endocrinology , Feb. 2025.
| DOI: | 10.3389/fendo.2025.1516433 |
T.
Lari,
L.
Macias,
L.
Robrahn,
H.
Dikmen,
J.
Prüßmann,
C.
Kiehne,
S.
Engster,
I.
Weyers,
S.
Szymczak,
N.
Beek,
M.
Hoffmann,
E.
Schmidt, and
S.
Emtenani,
Localization of Lesions in Autoimmune Blistering Diseases Is Independent of Site-Speicific Target Antigen Expression, Life , Jan. 2025.
Localization of Lesions in Autoimmune Blistering Diseases Is Independent of Site-Speicific Target Antigen Expression, Life , Jan. 2025.
| DOI: | 10.3390/life15020218 |
2024
C.
Saggau,
P.
Bacher,
D.
Esser,
M.
Rasa,
S.
Meise,
N.
Mohr,
N.
Kohlstedt,
A.
Hutloff,
S.
Schacht,
J.
Dargvainiene,
G.
Martini,
K.
Stürner,
I.
Schröder,
R.
Markewitz,
J.
Hartl,
M.
Hastermann,
A.
Duchow,
P.
Schindler,
M.
Becker,
C.
Bautista,
J.
Gottfreund,
J.
Walter,
J.
Polansky,
M.
Yang,
R.
Naghavian,
M.
Wendorff,
E.
Schuster,
A.
Dahl,
A.
Petzold,
S.
Reinhardt,
A.
Franke,
M.
Wieczorek,
L.
Henschel,
D.
Berger,
G.
Heine,
M.
Holtsche,
V.
Häußler,
C.
Peters,
E.
Schmidt,
S.
Fillatreau,
D.
Busch,
K.
Wandinger,
K.
Schober,
R.
Martin,
F.
Paul,
F.
Leypoldt, and
A.
Scheffold,
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases, Immunity , Oct. 2024.
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases, Immunity , Oct. 2024.
| DOI: | DOI: 10.1016/j.immuni.2024.08.005 |
K.
Stark,
B.
Kilani,
S.
Stockhausen,
J.
Busse,
I.
Schubert,
T.
Tran,
F.
Gaertner,
A.
Leuning,
K.
Pekayvaz,
L.
Nicolai,
V.
Fumagalli,
J.
Stermann,
F.
Stephan,
C.
David,
M.
M??ller,
B.
Heyman,
A.
Lux,
A.
Guerreiro,
L.
Frenzel,
C.
Schmidt,
A.
Dopler,
M.
Moser,
S.
Chandrarantne,
M.
Brühl,
M.
Lorenz,
T.
Korff,
M.
Rudelius,
O.
Popp,
M.
Kirchner,
P.
Mertins,
F.
Nimmerjahn,
M.
Iannacone,
M.
Sperandio,
B.
Engelmann,
A.
Verschoor, and
S.
Massberg,
Antibodies and complement are key drivers of thrombosis, Immunity , Sep. 2024.
Antibodies and complement are key drivers of thrombosis, Immunity , Sep. 2024.
| DOI: | 10.1016/j.immuni.2024.08.007 |
M.
Olbrich,
S.
Patzelt,
C.
Sadik,
E.
Schmidt, and
R.
Ludwig,
Risk of blindness in a global cohort of patients with mucous membrane pemphigoid, Pharmacological Research , Sep. 2024.
Risk of blindness in a global cohort of patients with mucous membrane pemphigoid, Pharmacological Research , Sep. 2024.
| DOI: | 10.1111/jdv.20499 |
J.
Tegtmeyer,
M.
Romagnuolo,
C.
Hammers,
B.
Opelka,
C.
Probst,
L.
Komorowski,
A.
Marzano,
E.
Schmidt, and
S.
Goletz,
Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease, Experimental Dermatology , Jun. 2024.
Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease, Experimental Dermatology , Jun. 2024.
| DOI: | DOI: 10.1111/exd.15125 |
S.
Preuß,
A.
Vorobyev,
E.
Moderegger,
P.
Terheyden,
K.
Bieber,
K.
Kridin,
P.
Joly, and
R.
Ludwig,
Pemphigoid gestationis is associated with an increases risk for adverse pregnancy outcomes: A large-scale propensity-matched retrospective cohort study, Journal of the American Academy of Dermatology , Jun. 2024.
Pemphigoid gestationis is associated with an increases risk for adverse pregnancy outcomes: A large-scale propensity-matched retrospective cohort study, Journal of the American Academy of Dermatology , Jun. 2024.
| DOI: | https://doi.org/10.1016/j.jaad.2024.05.087 |
A.
Bootz,
T.
Reuter,
F.
Nimmerjahn,
W.
Britt,
M.
Mach, and
T.
Winkler,
Functional Fc receptors are crucial in antibody-mediated protection against cytomegalovirus, European Journal of Immunology , Jun. 2024.
Functional Fc receptors are crucial in antibody-mediated protection against cytomegalovirus, European Journal of Immunology , Jun. 2024.
| DOI: | DOI: 10.1002/eji.202451044 |
N.
Beek,
M.
Holtsche,
I.
Atefi,
H.
Olbrich,
M.
Schmitz,
J.
Pruessmann,
A.
Vorobyev, and
E.
Schmidt,
State-of-the-art diagnosis of autoimmune blistering diseases, Frontiers in Immunology , Jun. 2024.
State-of-the-art diagnosis of autoimmune blistering diseases, Frontiers in Immunology , Jun. 2024.
| DOI: | 10.3389/fimmu.2024.1363032 |
M.
Olbrich,
A.
Hartmann,
S.
Künzel,
Z.
Aherrahrou,
P.
Schilf,
John F. Baines,
S.
Ibrahim, and
M.
Hirose,
Mitochondrial DNA variants and microbiota: An experimental strategy to identify novel therapeutic potential in chronic inflammation, Pharmacological Research , Jun. 2024.
Mitochondrial DNA variants and microbiota: An experimental strategy to identify novel therapeutic potential in chronic inflammation, Pharmacological Research , Jun. 2024.
| DOI: | 10.1016/j.phrs.2024.107231 |
| File: | j.phrs.2024.107231 |
N.
Gross,
J.
Marketon,
S.
Mousavi,
K.
Kalies,
R.
Ludwig, and
K.
Bieber,
Inhibition of interferon gamma impairs induction of experimental epidermolysis bullosa acquisita, Frontiers in Immunology , May 2024.
Inhibition of interferon gamma impairs induction of experimental epidermolysis bullosa acquisita, Frontiers in Immunology , May 2024.
| DOI: | 10.3389/fimmu.2024.1343299 |
| File: | full |
S.
Krohn,
T.
Holtrop,
A.
Brandsma,
P.
Moerer,
M.
Nederend,
N.
Darzentas,
M.
Brüggemann,
K.
Klausz,
J.
Leusen, and
M.
Peipp,
Combining Cellular Immunization and Phage Display Screening Results in Novel, FcgammaR1-Specific Antiboides, viruses , Apr. 2024.
Combining Cellular Immunization and Phage Display Screening Results in Novel, FcgammaR1-Specific Antiboides, viruses , Apr. 2024.
| DOI: | 10.3390/v16040596 |
M.
Pigors,
S.
Goletz,
Y.
Wang,
S.
Emtenani,
C.
Hammers,
M.
Holtsche,
S.
Patzelt,
B.
Opelka,
F.
Stang,
I.
König,
C.
Radzimski,
L.
Komorowski,
M.
Aumailley,
C.
Has, and
E.
Schmidt,
Anti-Laminin beta4 IgG Drives Tissue damage in Anti-p200 Pemphigoid and Shows Interaction with Laminin alpha3 and gamma1/2 Chains, Journal of Investigative Dermatology , Apr. 2024.
Anti-Laminin beta4 IgG Drives Tissue damage in Anti-p200 Pemphigoid and Shows Interaction with Laminin alpha3 and gamma1/2 Chains, Journal of Investigative Dermatology , Apr. 2024.
| DOI: | 10.1016/j.jid.2024.08.004 |
