The significance of immunological and neuronal responses to scratching for the effector phase of pemphigoid diseases

Intense pruritus (“itch”) is often the first and the most persistent symptom of pemphigoid diseases (PDs) and leads to scratching, which activates sensory nerve fibers and can result in epithelial damage. Both are known to recruit inflammatory cells and autoantibodies into the skin. B3 aims at identifying the inflammatory mechanisms leading to pruritus and the pathways linking neuronal activation and epithelial damage to inflammatory cell and antibody recruitment. B3 will thereby elucidate the role and mechanisms of pruritus and scratching in aggravating PDs.