Recent clinical and experimental evidence suggests a critical role of gut microbiota in modulating systemic immune cell functions and inflammatory responses. Yet, their involvement in pemphigoid diseases (PDs) has not been investigated. In this project, we aim to examine the connection between gut microbiota and skin inflammation using human PD patient biomaterial and murine PD models. A second major aim is to identify gut microbe-derived mediators as potential therapeutic options for PDs.