B02: G protein-coupled receptors orchestrating granulocytes in pemphigoid diseases

The behavior of granulocytes in tissue inflammation is regulated via cell surface receptors. G protein-coupled receptors (GPCRs) constitute the largest group of receptors. The expression of GPCRs is dynamic and determines the stimuli cell populations can respond to in their environment. B02 will profile the expression of GPCRs in granulocytes throughout the effector phase of a pemphigoid disease. Thus, it will identify functional granulocyte subpopulations and highlight stimuli regulating granulocyte behavior in pemphigoid diseases. B02 will uncover the pathogenic significance of select GPCRs for pemphigoid diseases.