Prof. Dr. med. Nina Wettschureck

Department of Pharmacology

Johan-Wolfgang-Goethe University Frankfurt/M and Max Planck Institute for Heart and Lung Research, Bad Nauheim
Ludwigstr. 43
61231 Bad Nauheim

Phone:+49 6032 705 1214


1. Carvalho J, Chennupati R, Li R, Günther S, Kaur H, Zhao W, Tonack S, Kurz M, Mößlein N, Bünemann M, Offermanns S, Wettschureck N. Orphan G-protein-coupled receptor GPRC5B controls smooth muscle contractility and differentiation by inhibiting prostacyclin receptor signaling. Circulation 2020 Apr 7;141(14):1168-1183

2. Kaur H, Carvalho J, Looso M, Singh P, Chennupati R, Preussner J, Günther S, Albarrán-Juárez J, Tischner D, Classen S, Offermanns S, Wettschureck N. Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. Nat Commun 2017; 8:15700; DOI: 10.1038.

3. Kaur H, Takefuji M, Ngai C, Carvalho J, Bayer J, Wietelmann A, Poetsch A, Hölper S, Conway SJ, Möllmann H, Looso M, Troidl C, Offermanns S, Wettschureck N. Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling. Circ Res 2016; 118:1906-17.

4. Chen H, Assmann JC, Krenz A, RahmanM, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N*, Schwaninger M*. Hydroxy-carboxylic acid receptor 2 mediates dimethyl fumarate‘s protective effect in EAE. J Clin Invest 2014; 124:2188-92. (*contributed equally)

5. Sivaraj KK, Takefuji M, Schmidt I, Adams RH, Offermanns S, Wettschureck N. G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell 2013; 25:427-34.

6. Takefuji M Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N. RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. J Exp Med 2013; 210: 665-673.

7. Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N. A G13-Mediated Signaling Pathway is Required for Pressure Overload-Induced Cardiac Remodeling and Heart Failure. Circulation 2012; 126: 1972-1982.

8. Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N. The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J Clin Invest 2010;120: 2184-93.

9. Herroeder S., Reichardt P., Sassmann A., Zimmermann B., Jaeneke D., Hoeckner J., Hollmann M.W., Fischer K.D., Vogt S., Grosse R., Hogg N., Gunzer M., Offermanns S., Wettschureck N. G-proteins of the G12/13 family shape immune functions by controlling CD4+ T-cell adhesiveness and motility. Immunity 2009; 30:708-20.

10.Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med 2001;7:1236-40.