Prof. Dr. rer. nat. Matthias Peipp

Internal Medicine II: Antibody-based Immunotherapy

Christian-Albrechts-University of Kiel
Rosalind-Franklin-Strasse 12
24105 Kiel

Email:m.peipp(at)med2.uni-kiel.de
Phone:+49 431 500 22769
Fax:

Publications

1. Pekar L, Klausz K, Busch M, Valldorf B, Kolmar H, Wesch D, Oberg HH, Krohn S, Boje AS, Gehlert CL, Toleikis L, Krah S, Gupta T, Rabinovich B, *Zielonka S, *Peipp M. Affinity Maturation of B7-H6 Translates into Enhanced NK Cell-Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement.. J Immunol 2021; 206:225-236 *contributed equally

2. Khodoun MV, Morris SC, Shao WH, Potter C, Angerman E, Kiselev A, Yarawsky AE, Herr AB, Klausz K, Otte A, *Peipp M, *Finkelman FD. Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs.. J Allergy Clin Immunol 2020; S0091- 6749(20)31729-2 *contributed equally

3. Schewe DM, Alsadeq A, Sattler C, Lenk L, Vogiatzi F, Cario G, Vieth S, Valerius T, Rosskopf S, Meyersieck F, Alten J, Schrappe M, Gramatzki M, *Peipp M, *Kellner C. An Fc engineered CD19 ntibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia

xenografts. Blood. 2017; 130:1543-1552 *contributed equally 4. Staudinger M, Glorius P, Burger R, Kellner C, Klausz K, Günther A, Repp R, Klapper W, Gramatzki M, Peipp M. The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells. Blood Cancer J 2014; 4:e219

5. *Oberg, HH, *Peipp, M, Kellner, C, Sebens, S, Krause, S, Petrick, D, Adam-Klages, S, Röcken, C, Becker, T, Vogel, I, Weisner, D, Freitag-Wolf, S, Gramatzki, M, Kabelitz, D, Wesch, D. Novel bispecific antibodies increase the γδ T-cell cytotoxicity against pancreatic ductal adenocarcinoma cells Cancer Res 2014; 74:1349-60 *contributed equally

6. Glorius, P, Baerenwaldt, A, Kellner, C, Staudinger, M, Dechant, M, Stauch, M, Beurskens, FJ, Parren, PW, Winkel, JG, Valerius, T, Humpe, A, Repp, R, Gramatzki, M, Nimmerjahn, F, Peipp, M. The novel tribody [(CD20)2xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells. Leukemia 2013; 27:190-201

7. Kellner, C, Zhukovsky, EA, Pötzke, A, Brüggemann, M, Schrauder, A, Schrappe, M, Kneba, M, Repp, R, Humpe, A, Gramatzki, M, Peipp, M The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patients Leukemia 2013; 27:1595-8

8. Kellner, C, Hallack, D, Glorius, P, Staudinger, M, Mohseni Nodehi, S, de Weers, M, van de Winkel, JG, Parren, PW, Stauch, M, Valerius, T, Repp, R, Humpe, A, Gramatzki, M, Peipp, M Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity. Leukemia 2012; 26:830-4

9. Kellner, C, Maurer, T, Hallack, D, Repp, R, van de Winkel, JG, Parren, PW, Valerius, T, Humpe, A, Gramatzki, M, Peipp, M (2012) Mimicking an Induced Self Phenotype by Coating Lymphomas with the NKp30 Ligand B7-H6 Promotes NK Cell Cytotoxicity. J Immunol 2012; 189:5037-46

10. Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Habiro K, Yang JG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Shultz LD, Lee SK, Shankar P. T cellspecific siRNA delivery suppresses HIV-1 infection in a humanized mouse model. Cell 2008; 134:577-586